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Erythropoietin Molecular, Cellular, and Clinical Biology (Johns Hopkins Series in Contemporary Medicine and Public Health) by Allan J. Erslev

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Published by The Johns Hopkins University Press .
Written in English


  • Renal medicine,
  • Testing,
  • Kidney Diseases,
  • Medical / Nursing,
  • Science/Mathematics,
  • Therapeutic use,
  • Environmental Science,
  • Hematology,
  • Medical / Hematology,
  • Chemotherapy,
  • Recombinant erythropoietin,
  • Renal anemia,
  • Anemia

Book details:

The Physical Object
Number of Pages472
ID Numbers
Open LibraryOL7869945M
ISBN 100801842212
ISBN 109780801842214

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In 15 papers, all from European centres, the broad topics covered are erythropoietin's physiology and chemistry, the patho­ physiology of erythropoiesis and the use of erythropoietin in the treatment of anaemia. Several of the papers include up-to-date reviews of the Wolfgang Jelkmann. Erythropoietin is a medicine available in a number of countries worldwide. A list of US medications equivalent to Erythropoietin is available on the website. Erythropoietin is a medicine available in a number of countries worldwide. A list of US medications equivalent to Erythropoietin is available on the website. Millions of patients worldwide have benefited from research on erythropoietin spanning many decades. In the last 15 years, epoetin alfa (Epo) has become one of the most widely used drugs created through recombinant DNA technology. Recombinant erythropoietin is a man-made version of natural erythropoietin. It is produced by cloning the gene for erythropoietin. Recombinant erythropoietin drugs are known as erythropoietin-stimulating agents (ESAs). These drugs are given by injection (shot) and work by .

Regulation of erythropoietin synthesis in the kidneys relies on a feedback loop in response to hypoxia (this is described in more detail elsewhere in the book). The expression of erythropoietin mRNA and protein is regulated primarily at the transcriptional level through the hypoxia-inducible transcription factor HIF (Blanchard et al., The book covers all aspects from developmental biology to specific topics such as medical applications of recombinant Epo, receptor biology, mechanisms of Epo activity, structure/activity relationship, disease states and important actions on non-hematopoietic organs and tissues, including the central nervous system, heart, gastrointestinal. The erythropoietin test measures the amount of a hormone called erythropoietin (EPO) in blood. The hormone tells stem cells in the bone marrow to make more red blood cells. EPO is made by cells in the kidney. These cells release more EPO when blood oxygen level is low. Erythropoietin is a hematopoietic hormone secreted by the kidney that functions as a major stimulator of the production of erythrocytes. Erythropoietin is a secreted glycoprotein of amino acids, but with a mature molecular mass of kDa due to the presence .

What is erythropoietin. Erythropoietin (EPO) is a hormone produced primarily by the healthy kidneys and a small amount in your liver 1).Erythropoietin prompts your bone marrow stem cells to make more red blood cells, which then carry oxygen from the lungs to the rest of your body. Serum erythropoietin and erythropoiesis in patients with myelodysplastic syndromes. Eur J Haematol. Jan; 44 (1)– Bowen D, Ehmer B, Neubert P, Lewis T, Jacobs A. The clearance of a single i.v. bolus of recombinant human erythropoietin from the serum of patients with myelodysplastic syndromes and its effects on by: erythropoietin [ĕ-rith″ro-poi´ĕ-tin] a glycoprotein hormone secreted by the kidney in the adult and by the liver in the fetus, which acts on stem cells of the bone marrow to stimulate red blood cell production (erythropoiesis). recombinant human erythropoietin epoetin. e·ryth·ro·poi·e·tin (EPO), (ĕ-rith'rō-poy'ĕ-tin), [MIM*] A protein. Oct 10,  · Introduction Chronic kidney disease (CKD) is a serious problem in the general population. There is a growing trend in prevalence and incidence of renal failure in the United States ().In this review, we compared the effects of erythropoietin and anemia Cited by: